Boc-Glu(OMe)-OH Boc-L-glutaMic acid γ-Methyl ester
BOC-GLU(OME)-OH
CAS: 45214-91-3
Molecular Formula: C11H19NO6
Boc-Glu(OMe)-OH Boc-L-glutaMic acid γ-Methyl ester - Names and Identifiers
Boc-Glu(OMe)-OH Boc-L-glutaMic acid γ-Methyl ester - Physico-chemical Properties
| Molecular Formula | C11H19NO6 |
| Molar Mass | 261.27 |
| Density | 1.182±0.06 g/cm3(Predicted) |
| Melting Point | 74-77 °C |
| Boling Point | 428.4±40.0 °C(Predicted) |
| Solubility | Chloroform (Sparingly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White |
| pKa | 3.82±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Physical and Chemical Properties | Boc-L-glutamic acid -5-methyl ester is an amino acid derivative, the molecule contains both acidic and basic groups, therefore, amino acids can react with stronger acids, it can also react with strong base to form stable salt, which has the characteristics of amphoteric compounds. It is mainly used in medicine to prepare compound amino acid infusion, and also used in the synthesis of polypeptide drugs. |
Boc-Glu(OMe)-OH Boc-L-glutaMic acid γ-Methyl ester - Reference Information
| preparation | at 0 ℃, slowly add ditert-butyl dicarbonate (10.2g, 1.2 equivalent) and triethylamine (19.0 ml) to a solution of (S)-2-amino-5-methoxy-5-oxopentanoate hydrochloride (7.70g, 1.0 equivalent) in dioxane (30 ml) and water (15 ml), 3.5 equivalent), stir the mixed solution at room temperature for 4 hours, then remove the solvent dioxane under reduced pressure, clean the reactants with ether, remove organic matter, acidify the water phase with hydrochloric acid (1M) to pH 4, extract the water phase with ethyl acetate, dry the combined organic phase with anhydrous magnesium sulfate, and finally remove the solvent under reduced pressure to obtain the target product Boc-L-glutamic acid -5-methyl ester. |
Last Update：2024-04-10 22:29:15
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